cortiQ is a new way of brain mapping for the operating room and neuro monitoring unit that is used with epilepsy or brain tumor patients. cortiQ determines functional areas as those whose electrocorticographic (ECoG) activity increases with tasks such as motor movement or speech production.
cortiQ allows neurologists and neurosurgeons to localize eloquent brain areas and provides additional information for surgical resection with a low risk of neurological deficits. cortiQ software can readily be used in addition to traditional mapping procedures such as electrical cortical stimulation (ECS) mapping or fMRI.
|real-time brain mapping in the operating room or neuro monitoring unit|
|minimize hospital time and costs|
|rapid mapping procedure|
|customizable for individual surgical needs|
|optimize surgical procedures|
|reduce risks for patients|
|can be used in very young patients, too|
|FDA cleared and CE123 certified medical product|
|ADC||24 Bit, one per channel|
|ECoG channels||80, 144 or 256|
|Oversampling||614.14 kHz to 2.4 kHz|
|Anti-aliasing||Ultra-steep in 2 co-processors|
Passive high-gamma mapping represents a physiologically elegant and clinically relevant paradigm shift for identifying essential cortical functions.Anthony Ritaccio, PhD, MD - Mayo Clinic, Florida, USA
I use ECoG electrodes for real-time brain mappings to find and interpret functional activity in the brain at the bed-side, and during awake craniotomy for brain surgery. I can reduce electrical cortical stimulations (ECS) to minimize related seizures and shorten clinical examinations. Otherwise, I would miss an opportunity to improve existing brain mapping procedures and learn the bigger picture.Kyousuke Kamada, PhD, MD - Hokashin Group Megumin Hospital, Sapporo, Japan
cortiQ mapping is based on passive recordings and statistical evaluations of ECoG, rather than on active electrical stimulation and visual observation of behavior. It can be used to map motor, expressive or receptive language, and other functions, and has been shown to have good concordance to results from other imaging techniques. Brain mapping can be achieved in minutes with adults or children, and performed in the extraoperative or intraoperative scenario.Dr. Christoph Guger - g.tec medical engineering GmbH
Epilepsy is a common neurological disorder that affects a large portion of the world population. Many of the affected people can control epileptic seizures with the use of medication, but for around 15–20% of this population, medication is not effective, and some of these patients choose surgery. Brain cancer is another reason for brain surgery. There are various types of brain tumors, and the aim of the surgery is to remove the tumor (or at least parts of it).
For patients who suffer from epilepsy or brain tumors, brain surgery is often part of the treatment. However, the overall goal of brain surgery is to remove affected brain tissue causing as little damage as possible to the healthy and eloquent brain areas.
Functional brain mapping of the cortex is an essential step when planning resective brain surgeries. Mapping techniques like electrical cortical stimulation (ECS) and functional magnetic resonance imaging (fMRI) are well-established in clinical practice. However, these procedures have disadvantages, since ECS is time consuming, can trigger seizures, and fMRI is not always reliable.
A passive brain mapping procedure based on electrocorticographic (ECoG) signals is a fast and precise mapping technique without the risk of causing pain or seizures. ECoG has repeatedly demonstrated that it can accurately identify cortical regions related to receptive and expressive language functions, motor functions and the somatosensory system in the brain. For that reasons, g.tec medical engineering developed the cortiQ rapid cortical mapping system.
cortiQ is a new rapid functional mapping technique of the cortex using the Electrocorticogram (EcoG) for patients who suffer from epilepsy with intractable seizure disorders or brain tumors. cortiQ helps surgeons identify functional brain regions with high-gamma activity before surgical resection. cortiQ maps the brain regions related to a certain task that the patient is performing. Neurosurgeons will be able to use and modify cortiQ paradigms based on individual surgical needs.
For example, if pathological tissue is close to the motor area, cortiQ will ask the patient to move arms, feet or even lips. The brain activity patterns produced during these movements will be transmitted in real-time to cortiQ, notifying the neurosurgeon what parts are important for a certain movement and therefore should remain untouched.
After successful implantation of cortiQ ECoG electrodes, there are two ways of how to perform the brain mapping: intra-operative or bedside. These two approaches open many more opportunities with a minimal risk for the patient.
A brand new feature of cortiQ is the real-time 3D visualization of brain activity.
Unlike ECS, cortiQ does not produce artificial seizures and cannot produce pain. However, ECS might be required in some cases.
Therefore, cortiQ can identify neural areas that are “active” in a task decided by the surgeon and thereby provide a fast pre-screening mechanism that might be used for optimized ECS mapping and surgical removal of affected tissue.
The awake surgery case is critical in time. First, a craniotomy is performed to implant the electrodes. Then functional real-time mappings are performed just before the brain tissue resection. Validation with ECS must be done during the surgery.
The bedside case usually requires two surgeries. In the first surgery, electrodes will be implanted and functional real-time mappings are performed at the bedside. Validation with ECS can be done at the beside, too. In the second surgery, electrodes will be removed and the affected brain tissue will be resected.
In this publication, we studied the activity of a patient’s brain while he looked at different objects. If we stimulated these areas, the patient reported seeing faces or colors, even if he was looking at something else! The results of this study help show how different parts of the brain perform different tasks, and could lead to safer, more precise brain surgery.
Yes. Here is a list of all import publications:
Yes, absolutely. In the first surgery, ECoG electrodes will be implanted, but the functional real-time mappings are performed in the Epilepsy Monitoring Unit. This allows neurosurgeons to modify test paradigms based on individual surgical needs. These tests can be performed repeatedly over a longer period of time. This gives the neurosurgeon more time to plan and optimize the surgical resection better with more detailed information and less preparatory work. cortiQ can greatly reduce the risk of artificial seizures during surgery and cannot produce pain for the patient. It’s less consuming and the risk of damage during surgery can be avoided.
Yes, cortiQ can be used for intraoperative monitoring of the brain. It allows real-time brain mappings in the operating room to identify functional brain regions with high-gamma activity before surgical resection. For example, if pathological tissue is close to the motor area, cortiQ will ask the patient to move arms, feet or even lips. The brain activity patterns produced during these movements will be transmitted in real-time to cortiQ, notifying the neurosurgeon what parts are important for a certain movement and therefore should remain untouched.
A mapping that highlights four activation maps usually lasts about 6 min.
Yes, cortiQ comes with a passive listening paradigm that maps the auditory cortex, including the receptive language area, and it can play back language related paradigms like picture naming tasks and map expressive language related cortical regions.
Support surgeons’ planning for brain surgeries by providing additional information about functional brain regions.
The activated neural network is highlighted based on natural behaviors, such as speech or movement. The ECS can only investigate symptoms caused by local dysfunction due to electrical stimulation.
The mapping procedure works with electrode grids and stereo-EEG recordings with depth electrodes.
cortiQ stores the recorded EEG synchronized with the mapping paradigm and provides an importer for MATLAB (The MathWorks Inc., USA). cortiQ mapping results are stored in CSV format for further comparison.
The supervisor can immediately check the quality of the mapping session and stop/change the paradigm at any time. No further offline processing is necessary.
The power of the high-gamma frequency band (60-170Hz) derived from electrocorticographic (ECoG) signals.
The system compares high-gamma activity in the ECoG during resting and active conditions. Changes in the power of the high-gamma band indicate activated neurons with respect to the electrode position. A group of highlighted electrode groups shows an activated neural network. The system updates the activation map in real-time.
This allows the user to interpret the activation during the experiment and to stop the paradigm anytime. The longer the paradigm lasts, the more noise is eliminated, and hence only task-related electrodes are highlighted. A recommended setup contains around 45s active and 45s resting state per task.
Neurosurgeons who want to get additional information about the eloquent cortex and other specific regions, and research groups who want to investigate functional regions of the cortex. Neurosurgeons also benefit from cortiQ’s ability to provide maps in real-time instead of hours or days. Patients benefit from reductions in the time needed for mapping, need for additional mapping procedures, chance of accidental seizures resulting from ECS, and the risk of accidental removal of too little or too much brain tissue.
Unlike ECS, cortiQ does not produce artificial seizures. CortiQ cannot produce dural pain caused by bad electrode contacts. CortiQ shows the neural areas involved in a given task and allows very fast pre-screening that may be used for planning ECS mapping and surgical removal of affected tissue.
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